Hyperchromic effect of collagen induced by human collagenase
نویسندگان
چکیده
منابع مشابه
Collagen and Collagenase
That rheumatic fever generally attacks children and rheumatoid arthritis usually occurs in adults may be due to an alteration in the target organ (collagen plus ground substance) with age. Perhaps young, growing collagen is more susceptible to the stimuli producing rheumatic fever, whilst the more metabolically inert adult collagen responds with rheumatoid change to factors as yet unknown. One ...
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15 صفحه اولCollagenase production by human dermis in vitro.
Isolated human dermis has been shown to produce a specific collagenase in vitro. Enzyme activity becomes detectable after two days of culture, reaches a peak on the fourth day, and then begins to decline. Like collagenase obtained from cultures of whole human skin, dermal collagenase is inhibited by human serum and EDTA. The possible sources of this enzyme are discussed. Collagenolytic activity...
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Although the M(r) 72,000 type IV collagenase (matrix metalloproteinase 2) has been implicated in a variety of normal and pathogenic processes, its activation mechanism in vivo is unclear. We have found that fibroblasts from normal and neoplastic human breast, as well as the sarcomatous human Hs578T and HT1080 cell lines, activate endogenous matrix metalloprotease 2 when cultured on type I colla...
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Bone samples from the iliac crest of patients with no signs of bone disorder were treated with collagenase to remove the collagen component and so allow detailed observation of the mineral hydroxyapatite. Both polished and unpolished surfaces were studied in the scanning electron microscope and they showed that the mineral component of bone is composed of small rounded units about 10 nm across ...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1986
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1986.tb09539.x